Cancer Services Trials Unit
Cancer Services at Barwon Health has a long and distinguished history conducting clinical research through a dedicated clinical trials unit established in 1997 at the Andrew Love Cancer Centre – the Cancer Services Trials Unit (previously known as the Haematology and Oncology Trials Team (HOTT)).
The unit conducts cooperative, investigator-initiated and sponsored phase 1b-III/IV studies across a wide range of haematological malignancies and solid tumours. Trials are selected by investigators according to scientific and ethical merit as well as clinical need, enabling local patients to access novel therapies in the first-line treatment setting or beyond second-line when patients are less likely to have readily available and accessible standard of care treatment options.
Our clinical trial portfolio has grown significantly in recent years and our aim is to provide patients with increasing access to clinical trials in line with the state government’s Victorian Cancer Plan. The CSTU is currently involved in 63 active trials featuring 550 patients, with 30 more now open for recruitment and 13 to commence soon. These trials span a range of cancer types including lymphoma, leukaemia, myeloma, breast, melanoma, lung, prostate, and urology.
Our research activity benefits our regional patients, minimising their requirement to travel to larger metropolitan centres to access the latest novel therapies.
Keen to find out more about clinical trials at Barwon Health?
Click here to watch CSTU trials in cancer and chemotherapy: Dr Chiara Bortolasci, Clinical Trials Manager, Cancer Services Trials Unit (CSTU), Barwon Health (5 min)
Research Areas
SKILLED internship program
In early 2019, the CSTU partnered with the VCCC to recruit students as part of the SKILLED internship program. This program provides a pathway for students to build role-specific clinical trial knowledge, experience and skills in a clinical trials unit. Prior to commencement onsite, students attend an intensive two week program on significant aspects of clinical trials including Good Clinical Practice, Informed Consent, Dangerous Goods Transportation and Global and Local regulatory bodies. As part of their 6-12 month program, students are required to complete a project in which they develop and implement a tool or strategy to improve workflow within their clinical trial unit.
This is a program which the CSTU are committed to continue support and be involved in each year and as such our unit also participated in the SKILLED program this year.
“I am thoroughly enjoying my internship with the Victorian Comprehensive Cancer Centre and my time with my allocated host site, Barwon Health. This unique program, which incorporates formal training, workshops and assessments, in combination with hands-on learning across a broad range of trial activities, enables me to expand my current research knowledge to gain relevant industry experience and professional competencies. In addition, exposure to ground-breaking cancer science and communication has been invaluable. The added challenge of managing oncology trials and implementing a site-improvement project in a complex COVID-19 environment has further enhanced my communication and problem-solving skills and provided opportunities for innovative study management. Participation in this internship has been instrumental in providing relevant industry experience with a solid foundation of understanding of medical oncology clinical trials. I am immensely grateful to have been afforded the opportunity to progress my development as a researcher and cancer services professional, and look forward to completing the second half of this program and embarking on my future career.” – Stephanie Cowdery, SKILLED Study Coordinator Intern 2020
Collaborating Organisations
Research Team
Research Staff
Director
Haematology Investigators
- A/Professor Philip Campbell, MB ChB FRCP FRACP FRCPath FRCPA, Head of Haematology
- Dr Shreerang Sirdesai, MBBS
- Dr Sumita Ratnasingham, AdvDipMedSci BMedSci MBBS FRACP FRCPA
- Dr Hannah Rose, MBBS (Hons) FRACP
Medical Oncology Investigators
- Dr David Campbell MBBS FRACP, Head of Medical Oncology,
- Dr Patricia Banks, MB BS Bsc(Hons) FRACP
- Dr Anna Lomax, MBBS BSc FRACP
- Dr Caitlin Murphy, MB BS(Hons) BA FRACP
- Dr Inger Olesen, MBBS (Hons) FRACPn
- Dr Madhu Singh, MBBS FRACP
- Dr Karen White, MBBS FRACP
- Dr Shu Fen Wong, BMedSci MBBS FRACO Master of Applied Science
Radiation Oncology Investigators
- Dr Michael Francis, MBBS FRANZCR
- Dr Andrew Hui, MBBS FRANZCR Mmed (clin epi)
Haematology & Oncology Trials Team
- Dr Chiara Bortolasci, BPharm, MSc, PhD, Clinical Trials Manager
- Sonja Gauci, Clinical Trial Team Leader
- Katrina Golden, Clinical Trial Team Leader
- Scott Betteridge, Clinical Trial Coordinator
- Roxanne Alexander, Clinical Trial Coordinator
- Lisa McGrenaghan, Clinical Trial Coordinator
- Mandy McPhee, Clinical Trial Coordinator
- Taylor Gardner, Clinical Trial Coordinator
- Bianca Sawyer, Clinical Trial Coordinator
- Chloe Ristevski, Clinical Trial Coordinator
- Adele Stronach, Clinical Trial Coordinator
- Emily Knights, Clinical Trial Coordinator
- Peta Pocock, Clinical Trial Coordinator
- Jacqui Hopwood, Administrative Assistant
- Jodie Toohey, Administrative Assistant
- Katherine Snowden, Clinical Trial Pharmacist
Research Students
SKILLED Interns:
- Justin Dennis
Research News
CSTU clinical trial uncovers a new treatment for chronic leukaemia
We are extremely proud to have contributed to the release of a new treatment for people suffering from a common form of chronic leukaemia.
CSTU led the recruitment and management of the local phase 3 clinical trial of Calquence, which was tested across the world and was found to be a useful treatment for chronic lymphatic leukaemia (CLL), particularly in patients with relapsed disease. The treatment has just been listed through the Pharmaceutical Benefits Scheme (PBS), meaning it is available to patients by prescription at an affordable price.
Local patients enrolled in the trial included Mr David Selway-Hoskins. As Mr Selway-Hoskins, 76, told the Geelong Advertiser, the drug's listing on the PBS was "absolutely" a good thing, and he will continue to take Calquence after its PBS listing.
Barwon Health Director of Cancer Services and Head of Haematology Philip Campbell said the listing was testament to the importance of clinical trials. "It's very exciting for patients, and essentially provides people with relapsed disease another treatment option in oral form.”
To read the full article from the Geelong Advertiser, click here.
Research Grants
- Commonwealth of Australia (Commonwealth) as represented by the Department of Health (DH) - ReViTALISE Project: Bridging the metro-regional trials gap by 2025: 2021-2026
- Victorian Cancer Agency (VCA) - Improving Rural Health Outcomes through the Regional Trials Network-Victoria: 2021-2023
Featured Publications
Clinical characteristics of Australian treatment-naïve patients with classical Hodgkin lymphoma from the lymphoma and related diseases registry. Nguyen J, Wellard C, Chung E, Cheah CY, Dickinson M, Doo NW, Keane C, Talaulikar D, Berkahn L, Morgan S, Hamad N, Cochrane T, Johnston AM, Forsyth C, Opat S, Barraclough A, Mutsando H, Ratnasingam S, Giri P, Wood EM, McQuilten ZK, Hawkes EA; Lymphoma and Related Diseases Registry investigators. Eur J Haematol. 2023 Apr;110(4):386-395. doi: 10.1111/ejh.13915. Epub 2022 Dec 28. PMID: 36539351 |
Acalabrutinib Versus Investigator's Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results. Ghia P, Pluta A, Wach M, Lysak D, Šimkovič M, Kriachok I, Illés Á, de la Serna J, Dolan S, Campbell P, Musuraca G, Jacob A, Avery EJ, Lee JH, Usenko G, Wang MH, Yu T, Jurczak W. Hemasphere. 2022 Nov 14;6(12):e801. doi: 10.1097/HS9.0000000000000801. eCollection 2022 Dec. PMID: 36398134 |
Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration. Abida W, Patnaik A, Campbell D, Shapiro J, Bryce AH, McDermott R, Sautois B, Vogelzang NJ, Bambury RM, Voog E, Zhang J, Piulats JM, Ryan CJ, Merseburger AS, Daugaard G, Heidenreich A, Fizazi K, Higano CS, Krieger LE, Sternberg CN, Watkins SP, Despain D, Simmons AD, Loehr A, Dowson M, Golsorkhi T, Chowdhury S; TRITON2 investigators. J Clin Oncol. 2020 Nov 10;38(32):3763-3772. doi: 10.1200/JCO.20.01035. Epub 2020 Aug 14. PMID: 32795228 |
Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study. Abida W, Campbell D, Patnaik A, Shapiro JD, Sautois B, Vogelzang NJ, Voog EG, Bryce AH, McDermott R, Ricci F, Rowe J, Zhang J, Piulats JM, Fizazi K, Merseburger AS, Higano CS, Krieger LE, Ryan CJ, Feng FY, Simmons AD, Loehr A, Despain D, Dowson M, Green F, Watkins SP, Golsorkhi T, Chowdhury S. Clin Cancer Res. 2020 Jun 1;26(11):2487-2496. doi: 10.1158/1078-0432.CCR-20-0394. Epub 2020 Feb 21. PMID: 32086346 |
Assessment and management of newly diagnosed classical Hodgkin lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance. Cochrane T, Campbell BA, Gangatharan SA, Latimer M, Khor R, Christie DRH, Gilbertson M, Ratnasingam S, Palfreyman E, Lee HP, Trotman J, Hertzberg M, Dickinson M. Intern Med J. 2021 Dec;51(12):2119-2128. doi: 10.1111/imj.15503. Epub 2021 Nov 22. PMID: 34505342 |
Support Our Research
Participate in a Clinical Trial
To find out about Clinical Trials currently underway at Barwon Health, click here.
Donate
Clinical trials require ongoing investment and there are several ways to support this amazing work.
You can make a donation today and contribute to an item on our research wish list, consider a bequest in your will, or establish a lasting legacy fund in your name. No matter what size, your philanthropic support with deliver an immediate impact.
To donate now or for more information and further discuss your support, please contact the Barwon Health Foundation.
Last Modified: Tuesday, 06 February 2024
Research Leads
A/Professor Philip Campbell
Director of Cancer Services and Head of Haematology
Dr David Campbell
Head of Medical Oncology
Dr Chiara Bortolasci
Clinical Trials Manager
Andrew Love Cancer Centre
70 Swanston Street
Geelong VIC 3220
Ph (03) 4215 2758
Fax (03) 4215 2835